Available now
Enclomiphene oral tablet
A once-daily tablet. No injections, no gels, no refrigeration.
Helps withLow energyLow sex driveMuscle and strengthKeeping fertility
From$/month
Enclomiphene for menYour Own Testosterone. Optimized Naturally.
A daily oral medication that helps your body make more of its own testosterone, instead of replacing it. No injections, and it usually keeps sperm production going. Provider-prescribed, with labs.
From $189/moOral, once dailyAvailable in all 50 states
How your body makes testosterone
1Brain (pituitary)Sends the signal: LH and FSH
Signal turned upSignal quiets down
2TestesMake testosterone and sperm
Your own production risesOwn production slows
3Your bodyEnergy, drive, strength
Enclomiphene turns up your brain's signal, so your testes make more testosterone and keep making sperm.
TRT supplies testosterone from outside. Your brain senses it and quiets the signal, so your testes make less, including sperm.
Is this you?
The Same Symptoms. A Different Approach.
If you have symptoms of low testosterone but want to treat them without taking testosterone itself, or TRT isn't offered in your state, enclomiphene may be what you're looking for.
Fatigue that lingers no matter how much you sleep
Strength and muscle gains that used to come easily now stall out
Body fat creeping up around your midsection
Drive and ambition that now take real effort
Lower sex drive
Brain fog
The science
How Enclomiphene Works — And Why It Is Different From TRT
Here's the science in plain words.
Your brain reads estrogen
Your brain checks estrogen levels to decide how hard to signal the testes. When it senses estrogen, it eases off.
Enclomiphene blocks that reading
Enclomiphene is a selective estrogen receptor modulator (SERM). It blocks estrogen receptors in the brain, so the brain thinks levels are low and sends more LH and FSH.
Your testes respond
More LH tells the testes to make more testosterone. More FSH supports sperm production. Your own system does the work.
In plain English
TRT gives your body testosterone from outside, and your own production slows down. Enclomiphene tells your body to make more of its own. Your testes stay active, and fertility is usually preserved.
What to Expect and When
- Weeks 1 to 4
Signaling starts
Hormone levels begin shifting. Some men notice subtle energy changes.
- Weeks 4 to 8
Levels rise
Labs typically show rising testosterone. Energy and mood often improve.
- Weeks 8 to 16
Fuller effects
Libido, strength and body composition changes develop.
- Month 4+
Maintenance
Labs confirm your levels, and your provider adjusts if needed.
Typical timing. Everyone responds differently.
How to choose
Enclomiphene vs Testosterone Replacement
Both treat low testosterone. Answer three questions to see which one your provider is likely to talk through first.
Do you want to have children, now or later?
Would you rather avoid injections?
Has a provider told you your testosterone is very low, or did a fertility-friendly option not work?
Answer the questions
We'll show you which option usually comes first. Your provider makes the final call from your labs.
EnclomipheneTRT
How it worksYour body makes more of its ownSupplies testosterone directly
FertilityUsually preservedSperm production drops
How you take itDaily oral tabletWeekly injection, daily gel, or oral
Controlled substanceNoYes (Schedule III)
AvailabilityAll 50 statesSelect states
Best whenYour testes can still respond (secondary low T)Levels are very low or the testes don't respond
Dosing
How to Take Enclomiphene
Once a day, by mouth.
Tips
- Take it at the same time every day.
- Keep taking it as prescribed even if you feel better quickly. Levels take weeks to settle.
- Report any vision changes, like blurring or spots, to your provider right away.
Is it right for me?
Who This Is Best For
Enclomiphene is for men whose own system can still respond.
✓Enclomiphene Is Particularly Well Suited For
- Men who want to keep their fertility or plan to have children
- Men in states where TRT isn't offered
- Men who'd rather not inject
- Younger men with secondary low testosterone, where the brain's signal is low
!Who it's not for
- Primary hypogonadism, where the testes can't respond (TRT may fit better)
- A history of blood clots
- Liver disease
- Uncontrolled thyroid or adrenal conditions
- A pituitary tumor
- Unexplained vision problems
TRT May Be a Better Fit If You
TRT may be a better fit if your levels are very low, enclomiphene didn't raise them enough, or fertility isn't a concern. Your provider decides from your labs.
Full transparency
What Labs Are Required
Labs confirm low testosterone and show whether enclomiphene is working.
Before you start
- Total and free testosterone, usually on two mornings
- LH and FSH, to check whether your brain's signal is the issue
- Estradiol
- A blood count and metabolic panel
- PSA for men 40 and over
While you're on it
- Testosterone, LH and estradiol to confirm it's working
- A blood count
- Follow-ups on a schedule your provider sets
Labs are drawn at a Quest or Labcorp location near you.
Pricing
Enclomiphene Pricing — Everything Included
One monthly price for your medication, provider care and ongoing labs.
Available now
Enclomiphene
From$189/month, billed every 4 weeks
- Your enclomiphene prescription
- Licensed provider visits and dose adjustments
- Ongoing monitoring labs
- Patient portal and messaging
Good to know about cost
- A one-time initial lab fee of $50 before your first prescription
- Cancel any time before your next billing date
Not included: care coaching. FSA and HSA accepted. Insurance isn't billed.
Side effects
Side Effects — What to Expect
Most men tolerate enclomiphene well. Here's what to watch for.
Common
Headache, hot flashes, mood changes, nausea or mild breast tenderness, usually in the first weeks.
Report right away
Vision changes like blurring or spots, leg swelling or pain, or chest pain or trouble breathing.
Estrogen
As testosterone rises, estrogen can rise too. It's checked on your labs.
Not the same as clomiphene
Clomiphene contains two forms, including zuclomiphene, which acts more like estrogen. Enclomiphene is the single form that does the work.
Works well with
Programs That Work Well With Enclomiphene
Separate programs your provider may pair with enclomiphene.
Enclomiphene + Sermorelin
Sermorelin supports sleep and recovery through growth hormone signaling.
Learn about sermorelinEnclomiphene + NAD+
NAD+ supports cellular energy, a different pathway.
Learn about NAD+Enclomiphene + Hair Restoration
Rising testosterone can affect hair in men who are prone to loss.
Hair restorationHow it works
From Assessment to First Dose — What to Expect
- Step 1
Take the quiz
About 5 minutes on your symptoms, goals and health history.
- Step 2
Get your labs
Visit a Quest or Labcorp near you.
- Step 3
Provider review
A provider licensed in your state reviews your labs, usually within 24 to 48 hours.
- Step 4
Treatment ships
If you're prescribed, it ships discreetly, with follow-up labs on your provider's schedule.
Enclomiphene Questions Answered
Straight answers. If your question isn't here, our care team will answer it.
Don't see your city? We serve all 50 states. See all enclomiphene locations we serve
Clomiphene contains two forms — enclomiphene and zuclomiphene. Zuclomiphene has estrogenic effects that can cause side effects including mood changes and visual disturbances. Enclomiphene is the purified form that provides the testosterone-stimulating benefit without the zuclomiphene component.
Yes. Because enclomiphene isn't a controlled substance, it's available through our provider network in all 50 states — unlike testosterone, which is restricted in some states.
No — this is one of enclomiphene's biggest advantages over TRT. Because it stimulates your own LH and FSH production, it usually preserves or can improve sperm production while raising testosterone.
Most men notice energy and mood improvements within 4 to 6 weeks. Labs often show rising testosterone within the first 4 to 8 weeks. Fuller effects on body composition and libido develop over 12 to 16 weeks.
Often, yes. Transitioning from TRT to enclomiphene is a clinical process your provider manages, with labs tracking the recovery of natural testosterone production during the switch.
Some men, particularly those with more significantly impaired natural production, don't respond fully to enclomiphene. Your labs will show whether levels are reaching the target range. If they aren't, your provider can discuss TRT as the next step.
Men with primary hypogonadism (where the testes can't respond), a history of blood clots, liver disease, uncontrolled thyroid or adrenal conditions, or a pituitary tumor. Your provider reviews your full history before prescribing.
Yes. Labs confirm low testosterone and show whether enclomiphene is working, before you start and on an ongoing basis.
Make more of your own.
Take the quiz, get your labs, and a licensed provider reviews whether enclomiphene fits.