Hormone therapy for perimenopause and menopauseYour Hormones Changed. Your Care Should Keep Up.

Provider-prescribed estradiol and progesterone, as a pill, patch, cream or vaginal option, plus non-hormonal choices. Personalized to your symptoms and history by a licensed provider.

$79/mo, billed $237 every 12 weeks. Available in all 50 states.

What are you feeling most?

Rate each one from 0 (none) to 3 (severe).

Hot flashes or night sweats
Trouble sleeping
Mood swings or anxiety
Vaginal dryness or pain with sex
Brain fog
Rate your symptoms

We'll show you which kind of treatment usually fits. Your provider makes the final call.

You are not imagining it

You Are Not Imagining It

These are real, measurable effects of falling estrogen and progesterone, and they're treatable.

Check any that sound familiar.

The science, made simple

How Estrogen and Progesterone Work — And Why Their Decline Matters

Here's what changes, in plain words.

Estrogen works all over your body

Estrogen helps control body temperature, sleep, mood, bone strength, and vaginal and bladder health. When it falls, those systems feel it.

Progesterone balances it

Progesterone protects the uterine lining when you take estrogen, and supports sleep. If you've had a hysterectomy, you may not need it.

HRT replaces what dropped

Hormone therapy uses estradiol, the same form of estrogen your ovaries make, at the lowest dose that eases your symptoms.

About the safety headlines

Fears about HRT come largely from a 2002 study of older hormone types in women who were, on average, past 60. Today's guidance supports HRT for many healthy women with symptoms, especially when started before 60 or within 10 years of menopause. Your provider weighs your personal risks.

What to Expect and When

  1. Weeks 1 to 4

    Adjusting

    Your body adjusts. Some women notice better sleep first.

  2. Weeks 4 to 8

    Relief

    Many women notice fewer hot flashes and steadier mood.

  3. Weeks 8 to 12

    Vaginal health

    Dryness and comfort improve. Energy and libido often return.

  4. Month 3+

    Full effect

    Your provider reviews how you feel and adjusts if needed.

Typical timing. Everyone responds differently.

Formulation options

Your Formulation Options — Clinician Recommended Based on Your Profile

Your provider recommends a form based on your symptoms, health history and preference. One price covers every option: $79/mo, billed $237 every 12 weeks.

Available now

Estradiol Pill + Progesterone

A daily oral estradiol tablet. Progesterone is added if you still have a uterus.

OralDaily
Helps withHot flashesNight sweatsSleepMood

Best for: Women who want a simple daily pill and have no liver or clotting concerns.

Available now

Estradiol Patch or Cream + Progesterone

Estradiol through the skin, by patch or daily cream. Progesterone is added if you have a uterus.

Patch or cream
Helps withHot flashesNight sweatsSleepMood

Best for: Women with certain liver or heart risk factors, or who prefer skin over a pill. Through-the-skin estrogen has a lower clot risk than pills.

Available now

Estradiol Vaginal Gel or Insert + Progesterone

Low-dose estrogen placed in the vagina, with very little reaching the rest of the body.

Vaginal
Helps withVaginal drynessPain with sexRecurrent UTIs

Best for: Women whose main symptoms are vaginal or urinary.

Available now

Non-Hormonal Options

Low-dose paroxetine or desvenlafaxine, which can reduce hot flashes without hormones.

OralDaily
Helps withHot flashesNight sweats

Best for: Women who can't take hormones, such as after a hormone-sensitive cancer or a blood clot, or who prefer not to.

PillPatch or cream
How oftenDailyPatch once or twice a week, cream daily
Clot riskSmall increaseLower than pills
Good ifYou want the simplest routineYou have liver or heart risk factors

Illustrations. Vaginal estrogen mainly treats local symptoms. Non-hormonal options mainly treat hot flashes.

Full transparency

Lab Testing for HRT — What to Expect

Labs aren't always needed. Your provider orders them based on your symptoms and history.

Labs your provider may order

  • FSH, to help confirm your menopause stage
  • Estradiol and progesterone baselines
  • A thyroid panel, since thyroid problems can feel like menopause
  • A metabolic panel for liver and kidney health
  • A lipid panel for heart health

Good to know

  • If labs are ordered, they're drawn at a Quest or Labcorp near you and billed directly by the lab
  • Many women in their 40s and 50s are diagnosed from symptoms alone
  • Your provider may also ask about recent mammograms and cervical screening

Is it right for me?

Who Qualifies — and Who Should Discuss Carefully

HRT is a well-studied option for many women. It isn't right for everyone.

Good Candidates

  • Women in perimenopause or menopause with bothersome symptoms
  • Ideally under 60, or within 10 years of your last period
  • Women willing to keep up with check-ins and routine screening

Who it's not for

  • Breast or endometrial cancer, now or in the past
  • A blood clot, stroke or heart attack
  • Active liver disease
  • Unexplained vaginal bleeding
  • Pregnancy
  • A known clotting disorder

If any of these apply, non-hormonal or vaginal-only options may still be possible. Your provider talks it through.

Side Effects — What to Expect

  • Breast tenderness, bloating or headaches in the first weeks
  • Spotting or irregular bleeding in the first 3 to 6 months on combined HRT
  • Mood changes that usually settle within 8 to 12 weeks

Contact your provider right away for

  • Bleeding after it had stopped, or very heavy bleeding
  • Leg pain or swelling, chest pain or sudden shortness of breath
  • A new breast lump

Pricing

HRT Pricing — Everything Included

One monthly price for your medication and provider care.

Hormone therapy
Hormone Replacement Therapy (HRT)Pill, patch/gel, vaginal cream/insert, or non-hormonal -- one price for every formulation
$79/mo, billed $237 every 12 wks

Lab fees, if ordered, are billed by the lab. Care coaching isn't included with HRT. FSA and HSA accepted.

How it works

How It Works — From Assessment to First Shipment

  1. Step 1

    Take the quiz

    About 5 minutes on your symptoms, cycle and health history.

  2. Step 2

    Provider review

    A provider licensed in your state reviews it, usually within 24 to 48 hours, and orders labs if needed.

  3. Step 3

    Treatment ships

    Your prescription ships discreetly from a U.S.-licensed pharmacy.

  4. Step 4

    Follow-ups

    Your provider checks in and adjusts your dose or form as you go.

HRT Questions Answered

Straight answers. If your question isn't here, our care team will answer it.

View the full FAQ

Don't see your city? We serve all 50 states. See all HRT locations we serve

Feel like yourself again.

Take the quiz. A licensed provider reviews your symptoms and history within 24 to 48 hours.